https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 A novel MMP12 locus Is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16959 -7), with independent replication in a second population (p = 0.0048, OR(95% CI) = 1.18(1.05–1.32); meta-analysis p = 2.6×10-8). The nearby gene, MMP12, was significantly over expressed in carotid plaques compared to atherosclerosis-free control arteries (p = 1.2×10-15; fold change = 335.6). Permutation analyses demonstrated improved significance for associations when accounting for age-at-onset in all four stroke phenotypes (p<0.001). Our results show that a covariate-informed design, by adjusting for age-at-onset of stroke, can detect variants not identified by conventional GWAS.]]> Wed 11 Apr 2018 17:21:31 AEST ]]> More localized automorphisms of the Cuntz algebras https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4295 Wed 11 Apr 2018 12:01:28 AEST ]]> Labeled trees and localized automorphisms of the Cuntz algebras https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17881 n which preserve both the diagonal and the core UHFsubalgebra. A general criterion of invertibility of endomorphisms yielding such automorphisms is given. Combinatorial investigations of endomorphisms related to permutation matrices are presented. Key objects entering this analysis are labeled rooted trees equipped with additional data. Our analysis provides insight into the structure of Aut(On) and leads to numerous new examples. In particular, we completely classify all such automorphisms of O₂ for the permutation unitaries in ⊗⁴M₂. We show that the subgroup of Out(O₂) generated by these automorphisms contains a copy of the infinite dihedral group Z ⋊ Z₂.]]> Sat 24 Mar 2018 07:56:19 AEDT ]]>